POS0444 DIAGNOSTIC VALUE OF HIGH-RESOLUTION PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY COMPARED TO CONVENTIONAL RADIOGRAPHY FOR DETECTING EROSIVE DISEASE IN RHEUMATOID ARTHRITIS

Background: Conventional radiography (CR) of the hands, wrists and feet is currently gold standard for assessing erosive damage in patients with rheumatoid arthritis (RA). However, CR prone to relatively low resolution projection superimposition due 2-dimensional imaging. Therefore, might not detect disease RA patients. High-resolution peripheral quantitative computed tomography (HR-pQCT) an imaging modality superior (82µm 3 ) all other modalities vivo. HR-pQCT limited by a smaller field view. it needs be illuminated, whether higher sufficient diagnosing despite Objectives: The objective was investigate High-Resolution Quantitative Computed Tomography just two metacarpophalangeal (MCP) joints can diagnose more having than conventional 44 wrist feet. Methods: In this single-centre cross-sectional study. Patients established (disease duration ≥ 5 years) were investigated CR. second third MCP dominant hand assessed erosions HR-pQCT. scored according Sharp/van der Heijde (SHS) method. Results: Three hundred fifty-four included. By CR, 67 (18.9%) classified non-erosive RA, 287 (81.1%) RA. 47 (70.1%) had (Figure 1). We found agreement between 274 (77.4%) sensitivity specificity (95%CI) when used as reference 89% (84 – 92) % 30% (19 42) %, respectively. Using reference, 84% (80 88) 38% (25 52) McNemar’s χ 2 test 2.45, p = 0.146. Conclusion: identifies which are seen at joint reclassified substantial number compared their state determined using from only fingers statistically different joints, Acknowledgements: authors, we want acknowledge Aarhus University, Danish Rheumatism Association, Novo Nordic Foundation A.P. Møller Fonden who have financially supported funding sources did any role collection, analysis interpretation data. authors grateful excellent assistance recruiting scheduling Mia Marie Remmer, Lone Thomasen Else Sloth Rousing. Disclosure Interests: Rasmus Klose-Jensen: None declared, Josephine Therkildsen: Anne-Birgitte Blavnsfeldt: Bente Langdahl Speakers bureau: Eli Lilly, Amgen, UCB, Gilead, Gideon-Richter, Grant/research support from: Nordisk Kresten Krarup Keller: Ellen-Margrethe Hauge MSD, Pfizer, Sobi., Roche, Novartis Foundation.